Human cop1
Web哪里可以找行业研究报告？三个皮匠报告网的最新栏目每日会更新大量报告，包括行业研究报告、市场调研报告、行业分析报告、外文报告、会议报告、招股书、白皮书、世界500强企业分析报告以及券商报告等内容的更新，通过最新栏目，大家可以快速找到自己想要的内容。 Web25 mei 2024 · It has been speculated that DET1 might function through COP1 to control HY5 protein levels, but the biochemical evidence has …
Human cop1
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Web27 jan. 2024 · Focal deletions of COP1 were observed at significant frequency across several cancer types, and COP1 loss was determined to be one of the mechanisms leading to c-Jun upregulation in human cancer. We therefore conclude that Cop1 is a tumor suppressor that functions, at least in part, by antagonizing c-Jun oncogenic activity. Web28 feb. 2016 · COP1 proteins are E3 ubiquitin ligases that regulate phototropism in plants and target transcription factors for degradation in mammals. The substrate-binding …
WebThe bimolecular complex formed by the tumor suppressor p53 and the ubiquitin ligase COP1, topographically visualized on a mica substrate, is characterized by a surprisingly high specificity and affinity, both at the single-molecule level and in bulk solution. We note that the p53–COP1 interaction is characterized by a higher affinity and by a ... WebCOP1 proteins are E3 ubiquitin ligases that regulate phototropism in plants and target transcription factors for degradation in mammals. The substrate- binding region of COP1 resides within a WD40-repeat domain that also binds to Trib proteins, the adaptors for C/EBPa degradation.
WebThe COP1-mediated degradation of p53 regulates cancer cell growth and apoptosis. Our results indicate that COP1 regulates human breast cancer cell proliferation and …
Web1 okt. 2002 · Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Isoform 2 does not interact with …
Web27 nov. 2024 · Hac1 is a transcription factor that executes the UPR by activating genes involved in ER homeostasis. The UPR, and the mechanism of activation by splicing of a specific mRNA, is conserved from yeast to humans. Mammalian cells have an IRE1 ortholog named ERN1. Likewise, HAC1 has a functional human homolog, XBP1 [ 9 ]. newlywed card gameWebCOP1 Name Type symbol Gene Model Type protein_coding Aliases AJ000535; AJ000536; L24437 Description Represses photomorphogenesis and induces skotomorphogenesis in the dark. Contains a ring finger zinc-binding motif, a coiled-coil domain, and several WD-40 repeats, similar to G-beta proteins. intraday management softwareWeb1 jul. 2014 · COP1 and members of the four SPA proteins are part of an E3 ubiquitin ligase that acts in darkness to ubiquitinate several transcription factors involved in light responses, thereby targeting them for degradation by the proteasome. While COP1 is also found in humans, SPA proteins appear specific to plants. newlywed budget templateWeb概述 产品名称 Anti-COP1抗体 [1E4] 参阅全部 COP1 一抗 描述 小鼠单克隆抗体 [1E4] to COP1 宿主 Mouse 经测试应用 适用于: WB, ICC/IF, IHC-P, Flow Cyt more details 种属反应性 与反应: Mouse, Human 免疫原 Recombinant fragment: CLRSFKGHIN EKNFVGLASN GDYIACGSEN NSLYLYYKGL SKTLLTFKFD TVKSVLDKDR KEDDTNEFVS … newlywed cardWeb7 mrt. 2024 · Recent studies reported that COP1 overexpression is associated with increased cell proliferation, transformation, and disease progression in a variety of cancer types. In this study, we investigated whether COP1 regulates p53-mediated cell cycle arrest and apoptosis in human breast cancer cell lines. Methods newlywed car decorationsWebPostdoctoral Fellow in Plant Molecular Biology. apr. 2024 - heden1 maand. Utrecht, Utrecht, Netherlands. As a post-doctoral researcher at Utrecht University, I have recently begun investigating the circadian clock and plant development, utilizing advanced biology techniques to explore the underlying mechanisms of these processes. intraday margin callWeb15 jul. 2024 · COP1 regulates the expression of light-responsive genes through the targeted degradation of multiple photomorphogenesis-promoting transcription factors, including ELONGATED HYPOCOTYL 5 (HY5) and... newlywed cake roll