Webb15 mars 2024 · By examining the occupancy of the Drosophila pleiohomeotic repressive complex (PhoRC) during embryogenesis, we revealed extensive co-occupancy at … Webb12 jan. 2024 · The latter assemble in multi-subunit complexes, of which two kinds, Polycomb Repressive Complex 1 (PRC1) and Polycomb Repressive Complex 2 (PRC2), act together to effect the repression of...
Dual functionality of cis-regulatory elements as developmental ...
WebbThe Polycomb repressive complex 2 (PRC2) is an essential chromatin regulatory complex involved in repressing the transcription of diverse developmental genes. WebbBy examining the occupancy of the Drosophila pleiohomeotic repressive complex (PhoRC) during embryogenesis, extensive co-occupancy was revealed at developmental enhancers. Using an established in vivo assay for PRE activity, it was demonstrated that a subset of characterized developmental enhancers can function as PREs, silencing transcription in … doli graphic
Gene Group: PHO REPRESSIVE COMPLEX - FlyBase
WebbUBP13 are implicated in polycomb repression , but the composition of associated protein complexes remains enigmatic. Additional PRCs have been described in animals, such as Drosophila pleiohomeotic repressive complex (PhoRC) that does not confer enzymatic activity ( , reviewed in the work of ). As histone modifications Webb21 dec. 2011 · Polycomb repressive complex 2: E(z), Esc, and Su(z)12 The conserved SET domain of E(z) provides histone methyltransferase (HMTase) activity for H3K27. Based on the structure resolved in the plant SET domain by crystallization [ 47 ], the secondary structures of insect SET domains are predicted to contain twelve β sheets and seven … Webb5 maj 2010 · We have investigated the role of polycomb repressive complexes (PRCs) in hematopoietic stem cells (HSCs) and progenitor populations. We show that mice with loss of function mutations in PRC2 components display enhanced HSC/progenitor population activity, whereas mutations that disrupt PRC1 or pleiohomeotic repressive complex are … putinovi dvojnici